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Divalproex Sodium (Depakote medication)

Divalproex sodium is used to treat various types of seizure disorders. Divalproex sodium is sometimes used together with other seizure medications. Divalproex sodium is also used to treat manic episodes related to bipolar disorder, manic depression, and to prevent migraine headaches. Divalproex sodium may also be used for purposes not listed in this medication guide. Depakote medication (divalproex sodium) dissociates to the valproate ion in the gastrointestinal tract. The mechanisms by which valproate exerts its therapeutic effects have not been established. It has been suggested that its activity in epilepsy is related to increased brain concentrations of gamma-aminobutyric acid (GABA).

Divalproex Used

Take Divalproex sodium (Depakote medication) exactly as prescribed by your doctor. Your dose may need to be changed if you do not get enough fluids each day. Drink plenty of water while you are taking this medication. Do not stop using Divalproex without first talking to your doctor, even if you feel fine. If you experience stomach irritation, take it with food. Try to take it at the same time every day. Mania Associated with Bipolar Disorder: The recommended starting dose for adults is 750 mg daily given in divided doses. Migraines: The recommended starting dose for adults is 250 mg twice a day.

Divalproex and Depakote Side Effects

If you notice other effects not listed below contact your doctor. Less serious side effects may include: unusual taste in your mouth, hair loss, drowsiness, enlarged breasts, diarrhea, weakness, tremor, upset stomach, changes in menstrual periods. Get emergency medical help if you have vomiting, dark urine, loss of appetite, yellowing of the skin or eyes (jaundice), low fever, stomach pain, nausea, hives, blood in urine, body aches, difficulty breathing, double vision, difficulty breathing, swollen glands, sore throat, skin pain.


The information on this web-site has a general character. This information cannot be used for self-treatment and self diagnosis. You should consult with your doctor or health care adviser regarding any specific instructions of your condition. The information is reliable, but we concede it could contain mistakes. We are not responsible for any direct, indirect, special or other damage caused by use of this information on the site and also for consequences of self-treatment.